Cover Image

Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease

Background: Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi (T. cruzi) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infection. The purpose of this work was to design an improved vaccine...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qiana L. Matthews (Author), Anitra L. Farrow (Author), Girish Rachakonda (Author), Linlin Gu (Author), Pius Nde (Author), Alexandre Krendelchtchikov (Author), Siddarth Pratap (Author), Shruti S. Sakhare (Author), Steffanie Sabbaj (Author), Maria F. Lima (Author), Fernando Villalta (Author)
Format:	Book
Published:	Case Western Reserve University, 2016-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.
by: Anitra L Farrow, et al.
Published: (2014)

Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase.
by: Shankar Suman, et al.
Published: (2018)

Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal
by: Xiaofen Huang, et al.
Published: (2021)

Functional epitopes on hepatitis E virions and recombinant capsids are highly conformation-dependent
by: Bin He, et al.
Published: (2020)

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.
by: Aniekanabassi N Udoko, et al.
Published: (2016)

Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells.
by: Ashutosh Arun, et al.
Published: (2022)

Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells
by: Ashutosh Arun, et al.
Published: (2022)

Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes.
by: Juan Mucci, et al.
Published: (2017)

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
by: Nicholas M. Kanaan, et al.
Published: (2017)

Assessment of Adipocyte Transduction Using Different AAV Capsid Variants
by: Stanislav Boychenko, et al.
Published: (2024)

Development of peptide-based lineage-specific serology for chronic Chagas disease: geographical and clinical distribution of epitope recognition.
by: Tapan Bhattacharyya, et al.
Published: (2014)

Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein
by: Liliane O. Ortlieb, et al.
Published: (2022)

Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients.
by: Guadalupe Romer, et al.
Published: (2023)

Looking for Novel Capsid Protein Multimerization Inhibitors of Feline Immunodeficiency Virus
by: Natalia Sierra, et al.
Published: (2018)

Aiming at the heart: the capsid protein of dengue virus as a vaccine candidate
by: Laura Lazo, et al.
Published: (2019)

Current progress in the development of a prophylactic vaccine for HIV-1
by: Lena J Gamble, et al.
Published: (2010)

Human adenovirus type 3 restores pharmacologically inhibited exosomal cargo in lung carcinoma cells
by: Ayodeji O. Ipinmoroti, et al.
Published: (2024)

HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.
by: María G Alvarez, et al.
Published: (2008)

Study of HPV16 L1 Capsid Seropositivity in Patients with Oral and Oropharyngeal Cancers
by: Shalini Kanaparti, et al.
Published: (2021)

Development of an indirect immunofluorescence assay for PCV3 antibody detection based on capsid protein
by: Lun Yao, et al.
Published: (2021)

Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism
by: Yuqiu Wang, et al.
Published: (2022)

Bibliometric analysis and visualization of research trends on HIV-1 capsid inhibitors (2000-2022)
by: Lin Sun, et al.
Published: (2023)

α-Defensin HD5 Stabilizes Human Papillomavirus 16 Capsid/Core Interactions
by: Neetu M. Gulati, et al.
Published: (2019)

Prediction of T-Cell Epitope
by: Hiromichi Tsurui, et al.
Published: (2007)

Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces
by: W. van der Wulp, et al.
Published: (2024)

Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.
by: Patrik Castiglioni, et al.
Published: (2017)

Immunological Analysis of Nodavirus Capsid Displaying the Domain III of Japanese Encephalitis Virus Envelope Protein
by: Kiven Kumar, et al.
Published: (2021)

Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development
by: Ming Tan, et al.
Published: (2019)

Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice
by: Daniel A. J. Mitchell, et al.
Published: (2017)

IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety.
by: Mathilde Guerbois, et al.
Published: (2013)

Bioinformatics analysis of rhinovirus capsid proteins VP1-4 sequences for cross-serotype vaccine development
by: Ahmed S. Alshrari, et al.
Published: (2021)

Recombinant Outer Capsid Glycoprotein (VP7) of Rotavirus Expressed in Insect Cells Induces Neutralizing Antibodies in Rabbits
by: H Keyvani, et al.
Published: (2012)

Recombinant Outer Capsid Glycoprotein (VP7) of Rotavirus Expressed in Insect Cells Induces Neutralizing Antibodies in Rabbits
by: M Khodabandehloo, et al.
Published: (2012)

Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model
by: Karina Spunde, et al.
Published: (2022)

Epitope Discovery and Synthetic Vaccine Design
by: Clarisa Beatriz Palatnik-de-Sousa
Published: (2018)

Significance of antigen and epitope specificity in tuberculosis
by: Tom H.M. Ottenhoff
Published: (2014)

Identification of a critical role for ZIKV capsid α3 in virus assembly and its genetic interaction with M protein.
by: Anastazia Jablunovsky, et al.
Published: (2024)

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability
by: Lei Wang, et al.
Published: (2021)

Random Insertion of mCherry Into VP3 Domain of Adeno-associated Virus Yields Fluorescent Capsids With no Loss of Infectivity
by: Justin Judd, et al.
Published: (2012)

Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery
by: Zhixiang Cui, et al.
Published: (2023)