Optimization of HILIC method for the analysis of bisoprolol and its impurities considering uncertainties in peak position

• Main Authors: Rakić Tijana (Author), Jovanović Marko (Author), Tumpa Anja (Author), Jančić-Stojanović Biljana (Author), Medenica Mirjana (Author)
• Format: Book
• Published: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This paper presents the robust optimization of hydrophilic interaction liquid chromatographic method for the analysis of bisoprolol and its impurities A and C. Chemometric strategy is applied for detailed understanding of system's behavior and establishing the mathematical relationship between...