Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of <i>Nigella sativa</i> Oil in a Rat Model of Arthritis
This study investigated the preventive efficacy of the crude oil extracted from <i>Nigella sativa</i> seeds in a rat model of arthritis induced by using complete Freund’s adjuvant (CFA). <i>Nigella sativa</i> oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 an...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2019-08-01T00:00:00Z.
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| Summary: | This study investigated the preventive efficacy of the crude oil extracted from <i>Nigella sativa</i> seeds in a rat model of arthritis induced by using complete Freund’s adjuvant (CFA). <i>Nigella sativa</i> oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from the day of immunization. One immunized group was treated orally with indomethacin (3 mg/kg) as a reference drug. Body weight growth rate, paw swelling, arthritis score, mechanical allodynia, locomotor activity and anxiety-like behavior were observed, and the levels of Interleukin 6 (IL-6), C-reactive protein, albumin and total cholesterol in plasma were measured on days 15 and 25. <i>Nigella sativa</i> oil showed anti-inflammatory, anti-arthritic and anti-nociceptive activities that were significant as compared to untreated arthritic rats but less than indomethacin. These results indicated that <i>Nigella sativa</i> oil significantly attenuated adjuvant-arthritis in rats and the higher dose (1.82 mL/kg) prevented the development of arthritis with an inhibition of 56%. |
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| Item Description: | 2076-3921 10.3390/antiox8090342 |