63 Chemical inhibition of SWI/SNF induces transformed growth in non-mutant cells, mimicking the effects of a SMARCA4 mutation associated with small cell carcinoma of the ovary, hypercalcemic type

• Main Authors: Adam J. Krieg (Author), Sonali Joshi (Author), Shawn Campbell (Author), Tanja Pejovic (Author)
• Formato: Livro
• Publicado em: Elsevier, 2023-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objectives: Using a chemical inhibitor of the SWI/SNF complex (BRM014), we sought to determine if non-cancerous cells harboring wild-type SMARCA4 would spontaneously transform during in vitro culture, thereby providing a new model system for studying the formation of SCCOHT. Methods: Ovarian cells d...