Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance

• Main Authors: Stella Cellier-Goetghebeur (Author), Kiana Lafontaine (Author), Claudèle Lemay- (Author), Princesse Tsamo (Author), Alexis Bonneau-Burke (Author), Janine N. Copp (Author), Joelle N. Pelletier (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type B dihydrofolate reductases (DfrB) are intrinsically highly resistant to the widely used antibiotic trimethoprim, posing a threat to global public health. The ten known DfrB family members have been strongly associated with genetic material related to the application of antibiotics. Several <...