Prognostic value of C-reactive protein-to-albumin ratio and inflammatory markers in esophageal cancer patients treated with chemoradiotherapy
<b>Background:</b> This retrospective research, it was aimed to evaluate disease-free survival (DFS) using inflammatory markers in esophageal cancer patients who received chemoradiotherapy (CRT).<br /> <b>Methods</b>: A total of 67 patients who received standard curati...
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National Scientific Medical Center,
2021-03-01T00:00:00Z.
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| Summary: | <b>Background:</b> This retrospective research, it was aimed to evaluate disease-free survival (DFS) using inflammatory markers in esophageal cancer patients who received chemoradiotherapy (CRT).<br /> <b>Methods</b>: A total of 67 patients who received standard curative chemoradiotherapy for esophageal cancer were included in the study between 2011-2018. The patient, treatment characteristics, and pretreatment inflammatory markers were obtained from the patient's file.<br /> <b>Results </b>: Median follow up time was 18 months (6-72 months). ROC curve analyses showed the C-Reactive Protein-to-Albumin (CAR) cut-off value 0.9 for DFS (AUC:78.8%; sensitivity: 85%; specificity; 67.5%). 2-year disease free survival for CAR ≥0.9 and CAR <0.9 were 45.7% and 78%, respectively ( <i>P</i>=0.035). The radiation doses >50Gy (versus <50Gy, p=0.027) and CAR ratio < 0.9 (versus ≥ 0.9, p=0.005) appeared significant associates of better DFS in univariate analyses, but the age, gender, stage, localization, neutrophil-to-lympocyte ratio (NLR) and platelet-to-lymhocyte ratio (PLR) were no statistically significant (p>0.005).On the multivariate logistic analysis, our results showed that CAR < 0.9 [hazard ratio (HR) 1.29; 95% confidence interval [CI], 1.336-2.946; <i>P</i> = 0.014]; and radiation dose >50 Gy (HR 0.91; 95% CI, 1.229-4.997; <i>P</i> = 0.027) independent prognostic indictors.<br /> <b>Conclusion: </b>Our study found that the C-Reactive Protein/Albumin ratio is easy to apply and maybe a promising marker to predict disease-free survival in esophageal cancer patients who received chemoradiotherapy. |
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| Item Description: | 1812-2892 2313-1519 10.23950/jcmk/10802 |