Hyperplastic callus formation in congenital insensitivity to pain: A masquerader of osteosarcoma
Background: Congenital insensitivity to pain (CIP) is a rare genetic disorder characterized by the inability to experience pain. Unrecognized, repeated injuries may result in poorly healed fractures with hyperplastic callus formation, auto-amputation of digits, and osteomyelitis. In addition, the lo...
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| Format: | Book |
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Elsevier,
2023-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_bd8b78e358f54a2a98de5738d97bde4c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Maha Anwar |e author |
| 700 | 1 | 0 | |a Maha Rashid Malik |e author |
| 700 | 1 | 0 | |a Shaarif Bashir |e author |
| 700 | 1 | 0 | |a Usman Hassan |e author |
| 700 | 1 | 0 | |a Alina Sadaf |e author |
| 245 | 0 | 0 | |a Hyperplastic callus formation in congenital insensitivity to pain: A masquerader of osteosarcoma |
| 260 | |b Elsevier, |c 2023-03-01T00:00:00Z. | ||
| 500 | |a 2468-1245 | ||
| 500 | |a 10.1016/j.phoj.2022.12.009 | ||
| 520 | |a Background: Congenital insensitivity to pain (CIP) is a rare genetic disorder characterized by the inability to experience pain. Unrecognized, repeated injuries may result in poorly healed fractures with hyperplastic callus formation, auto-amputation of digits, and osteomyelitis. In addition, the loss of joint proprioception leads to neuropathic osteoarthropathy (Charcot joints). Case report: A child with a progressively increasing swelling of the left proximal tibia and an aggressive bone lesion on imaging was suspected to have osteosarcoma. The diagnosis of hyperplastic callus formation was established through a multidisciplinary approach with imaging and repeat tissue biopsy. Conclusion: In the context of CIP, malignant bone tumors, including osteosarcoma are a differential diagnosis and require a review of history, examination, radiology and histology. | ||
| 546 | |a EN | ||
| 690 | |a Osteosarcoma | ||
| 690 | |a Congenital insensitivity to pain with anhidrosis | ||
| 690 | |a Hyperplastic callus formation | ||
| 690 | |a Hereditary sensory and autonomic neuropathy type IV | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pediatric Hematology Oncology Journal, Vol 8, Iss 1, Pp 10-13 (2023) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S246812452200540X | |
| 787 | 0 | |n https://doaj.org/toc/2468-1245 | |
| 856 | 4 | 1 | |u https://doaj.org/article/bd8b78e358f54a2a98de5738d97bde4c |z Connect to this object online. |