Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study

Abstract Background Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these patterns in children with dengue infection would help to anticipate the...

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Main Authors: Grace Angeline Malarnangai Kularatnam (Author), Eresha Jasinge (Author), Sunethra Gunasena (Author), Dulani Samaranayake (Author), Manouri Prasanta Senanayake (Author), Vithanage Pujitha Wickramasinghe (Author)
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Published: BMC, 2019-04-01T00:00:00Z.
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001 doaj_be215672f3b54a839d88da34df1b938b
042 |a dc 
100 1 0 |a Grace Angeline Malarnangai Kularatnam  |e author 
700 1 0 |a Eresha Jasinge  |e author 
700 1 0 |a Sunethra Gunasena  |e author 
700 1 0 |a Dulani Samaranayake  |e author 
700 1 0 |a Manouri Prasanta Senanayake  |e author 
700 1 0 |a Vithanage Pujitha Wickramasinghe  |e author 
245 0 0 |a Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study 
260 |b BMC,   |c 2019-04-01T00:00:00Z. 
500 |a 10.1186/s12887-019-1451-5 
500 |a 1471-2431 
520 |a Abstract Background Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these patterns in children with dengue infection would help to anticipate the progression to different clinical stages thus enabling effective management. Methods A prospective follow up study was conducted during the period of July 2013 - April 2014 at Professorial Pediatric unit, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. Children (5-12 years) admitted within the first 84 h of fever, with a clinical diagnosis of dengue infection were recruited. Children who became positive for dengue IgM were included in the final analysis. Blood was collected on admission for complete blood count, Alanine aminotransferase, Aspartate aminotransferase, albumin, cholesterol and corrected calcium. These tests were repeated at 12 hourly intervals during the hospital stay. Results Data of 130-subjects were analyzed (Dengue fever /Dengue hemorrhagic fever: 100/30). There was a significant difference in the pattern of white cell counts, platelets and haematocrit in the two clinical groups. Both transaminase rose initially in both dengue fever and dengue hemorrhagic fever and a steep rise were seen between 8th and 9th days in hemorrhagic fever. Both albumin and cholesterol decreased significantly at the time of entering into the critical phase. According to Receiver operating characteristic curve analysis, albumin level crossing 37.5g/L (sensitivity 86.7%, specificity 77.8%) and a 0.38 mmol/L reduction in cholesterol level (sensitivity 77.3%, specificity 71.9%) between day 3 and 4 were the best predictors of entering into critical phase. Calcium levels did not show any distinct pattern. Conclusions There is a clear difference in the pattern of change of both hematological and biochemical parameters in dengue fever and dengue hemorrhagic fever. Reduction in albumin and cholesterol levels seen between the completion of day 3 and day 4 were highly valid predictors of entering into critical phase in dengue hemorrhagic fever. 
546 |a EN 
690 |a Dengue fever 
690 |a Dengue haemorrhagic fever 
690 |a Complete blood count 
690 |a Liver transaminases 
690 |a Calcium 
690 |a Cholesterol 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n BMC Pediatrics, Vol 19, Iss 1, Pp 1-9 (2019) 
787 0 |n http://link.springer.com/article/10.1186/s12887-019-1451-5 
787 0 |n https://doaj.org/toc/1471-2431 
856 4 1 |u https://doaj.org/article/be215672f3b54a839d88da34df1b938b  |z Connect to this object online.