Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients

• Main Authors: Biagio Rapone (Author), Ilaria Converti (Author), Luigi Santacroce (Author), Francesca Cesarano (Author), Federico Vecchiet (Author), Luciano Cacchio (Author), Salvatore Scacco (Author), Roberta Grassi (Author), Felice Roberto Grassi (Author), Antonio Gnoni (Author), Elisabetta Ferrara (Author), Gianna Maria Nardi (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<strong>Background:</strong> Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. <strong>Aim:</strong> The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. <strong>Materials and Methods:</strong> The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. <strong>Results:</strong> At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. <strong>Conclusions:</strong> Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS.

Item Description

2079-6382
10.3390/antibiotics8040209