Omslagsbild

Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis

Polygoni Multiflori Radix (PMR), the dried root of Polygonum Multiflorum Thunb., has been widely used as traditional Chinese medicines in clinical practice for centuries. However, the frequently reported hepatotoxic adverse effects hindered its safe use in clinical practice. This study aims to explo...

Full beskrivning

Sparad:

Bibliografiska uppgifter
Huvudupphovsmän:	Li Kang (Författare, medförfattare), Dan Li (Författare, medförfattare), Xin Jiang (Författare, medförfattare), Yao Zhang (Författare, medförfattare), Minhong Pan (Författare, medförfattare), Yixin Hu (Författare, medförfattare), Luqin Si (Författare, medförfattare), Yongjun Zhang (Författare, medförfattare), Jiangeng Huang (Författare, medförfattare)
Materialtyp:	Bok
Publicerad:	Frontiers Media S.A., 2022-05-01T00:00:00Z.
Ämnen:	article
Länkar:	Connect to this object online.
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!

Liknande verk

Hepatotoxic metabolites in Polygoni Multiflori Radix- Comparative toxicology in mice
av: Shixiao Wang, et al.
Publicerad: (2022)

Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis
av: Yihang Dai, et al.
Publicerad: (2023)

Metabolomics profiling of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata extracts using UPLC-Q/TOF-MS
av: Zhaoyan Zhang, et al.
Publicerad: (2019)

Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata
av: Dan Gao, et al.
Publicerad: (2016)

Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats
av: Wenhao Cheng, et al.
Publicerad: (2022)

Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix
av: Li Liang, et al.
Publicerad: (2018)

Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics
av: Jin-Fa Tang, et al.
Publicerad: (2017)

Detection of Emodin Derived Glutathione Adduct in Normal Rats Administered with Large Dosage of Polygoni Multiflori Radix
av: Li-Long Jiang, et al.
Publicerad: (2017)

Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury
av: Wei-Song Kong, et al.
Publicerad: (2022)

Comparison of raw and processed <it>Radix Polygoni Multiflori </it>(<it>Heshouwu</it>) by high performance liquid chromatography and mass spectrometry
av: Liang Zhitao, et al.
Publicerad: (2010)

Polygoni Multiflori Radix Praeparata Ethanol Extract Exerts a Protective Effect Against High-Fat Diet Induced Non-Alcoholic Fatty Liver Disease in Mice by Remodeling Intestinal Microbial Structure and Maintaining Metabolic Homeostasis of Bile Acids
av: Xuyang Dai, et al.
Publicerad: (2021)

Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway
av: Yu L, et al.
Publicerad: (2020)

Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D-galactose by bioassay method
av: Jiang Yan Huo, et al.
Publicerad: (2016)

Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins
av: Funan Ning, et al.
Publicerad: (2021)

2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis
av: Yu-Tang Chin, et al.
Publicerad: (2016)

<i>Caulis Polygoni Multiflori</i> Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways
av: Xin Yang, et al.
Publicerad: (2022)

Polygoni Cuspidati Rhizoma et Radix extract attenuates high-fat diet-induced NAFLD in rats: Impact on untargeted serum metabolomics and liver lipidomics
av: Huan Zhang, et al.
Publicerad: (2023)

Role of anthraquinones in combating insulin resistance
av: Wanru Xia, et al.
Publicerad: (2023)

The role of mitochondria in redox signaling of muscle homeostasis
av: Li Li Ji, et al.
Publicerad: (2020)

Oral Wound Healing Potential of <i>Polygoni Cuspidati Rhizoma et Radix</i> Decoction-In Vitro Study
av: Jakub Hadzik, et al.
Publicerad: (2023)

Pharmacokinetics of Anthraquinones from Medicinal Plants
av: Dongpeng Wang, et al.
Publicerad: (2021)

Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns
av: Meng Li, et al.
Publicerad: (2023)

Detoxification technology and mechanism of processing with Angelicae sinensis radix in reducing the hepatotoxicity induced by rhizoma Dioscoreae bulbiferae in vivo
av: Lingling Song, et al.
Publicerad: (2022)

Long-chain alkanol-alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma
av: Anqi Huang, et al.
Publicerad: (2022)

Identification of metabolites of Radix Paeoniae Alba extract in rat bile, plasma and urine by ultra-performance liquid chromatographyâquadrupole time-of-flight mass spectrometry
av: Zheng-Wei Chen, et al.
Publicerad: (2014)

Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis
av: Xiaoyong Xue, et al.
Publicerad: (2021)

Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase
av: Congcong Chen, et al.
Publicerad: (2023)

Calculus Bovis Sativus Improves Bile Acid Homeostasis via Farnesoid X Receptor-Mediated Signaling in Rats With Estrogen-Induced Cholestasis
av: Dong Xiang, et al.
Publicerad: (2019)

"Quantity-effect" research strategy for comparison of antioxidant activity and quality of Rehmanniae Radix and Rehmannia Radix Praeparata by on-line HPLC-UV-ABTS assay
av: Hong-Ying Li, et al.
Publicerad: (2020)

Naturally Occurring TPE-CA Maintains Gut Microbiota and Bile Acids Homeostasis via FXR Signaling Modulation of the Liver-Gut Axis
av: Linlin Liu, et al.
Publicerad: (2020)

Huangqi Decoction Alleviates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis by Reversing Disordered Bile Acid and Glutathione Homeostasis in Mice
av: Jia-Sheng Wu, et al.
Publicerad: (2017)

Study on the mechanism of acute liver injury protection in Rhubarb anthraquinone by metabolomics based on UPLC-Q-TOF-MS
av: Xiaohong Gong, et al.
Publicerad: (2023)

FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice.
av: Beibei Zhang, et al.
Publicerad: (2022)

Bile acid metabolism regulatory network orchestrates bone homeostasis
av: Tingwen Xiang, et al.
Publicerad: (2023)

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis
av: Zhaojuan Guo, et al.
Publicerad: (2021)

Simultaneous Quantitation of a Novel α1/β1-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion
av: Wenwen Zhu, et al.
Publicerad: (2019)

Enteric Polymer-Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation
av: Yuling Qin, et al.
Publicerad: (2022)

Regulation of Iron Homeostasis and Related Diseases
av: Yikun Li, et al.
Publicerad: (2020)

Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish <i>Megalobrama amblycephala</i> Offered a High-Carbohydrate Diet
av: Yaping Ge, et al.
Publicerad: (2023)

Oral Bioavailability of Kinsenoside in Beagle Dogs Measured by LC-MS/MS: Improvement of Ex Vivo Stability of a Lactone-Containing Compound
av: Xin Zhang, et al.
Publicerad: (2018)