Biliverdin Reductase: a Target for Cancer Therapy?

• Egile Nagusiak: Peter eGibbs (Egilea), Tihomir eMiralem (Egilea), Mahin D Maines (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways. Activation of certain kinases in these pathways is/are hallmark(s) of cancerous cells. The protein...