Identification of the Hepatic Metabolites of Flumazenil and their Kinetic Application in Neuroimaging

• Main Authors: Wei-Hsi Chen (Author), Chuang-Hsin Chiu (Author), Shiou-Shiow Farn (Author), Kai-Hung Cheng (Author), Yuan-Ruei Huang (Author), Shih-Ying Lee (Author), Yao-Ching Fang (Author), Yu-Hua Lin (Author), Kang-Wei Chang (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABA_A (type A) receptors for benzodiazepine ligands. Flumazenil antagonizes the benzodiazepine-bi...