Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker
Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo. Meanwhile, genotype is a key factor affecting pyrotinib clearance and 4β-hydroxycholesterol is an endogenous...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-09-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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