Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker

• Main Authors: Miao Zhang (Author), Zhiheng Yu (Author), Xueting Yao (Author), Zihan Lei (Author), Kaijing Zhao (Author), Wenqian Wang (Author), Xue Zhang (Author), Xijing Chen (Author), Dongyang Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo. Meanwhile, genotype is a key factor affecting pyrotinib clearance and 4β-hydroxycholesterol is an endogenous...