In vitro anti-HSV-1 activity of a chemically sulfated galactomannan from Leucaena leucocephala seeds
A galactomannan extracted from the seeds of Leucaena leucocephala was sulfated chemically, yielding a polymer (LLS-2) with 15.2% sulfate by weight (degree of sulfation 0.60), and its effect on the replication of Herpes simplex virus 1 (HSV-1) in Vero cells was investigated. When added during infecti...
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São Paulo State University (UNESP),
2010-05-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_be9b1ea6a5e9481f95e2cce7ad3b7536 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a E. Gemin |e author |
| 700 | 1 | 0 | |a C.E.O. Ferreira |e author |
| 700 | 1 | 0 | |a M.R. Sierakowski |e author |
| 700 | 1 | 0 | |a T.R. Jorge |e author |
| 700 | 1 | 0 | |a M.E.G. Joineau |e author |
| 700 | 1 | 0 | |a L. Ono |e author |
| 245 | 0 | 0 | |a In vitro anti-HSV-1 activity of a chemically sulfated galactomannan from Leucaena leucocephala seeds |
| 260 | |b São Paulo State University (UNESP), |c 2010-05-01T00:00:00Z. | ||
| 500 | |a 1808-4532 | ||
| 500 | |a 2179-443X | ||
| 520 | |a A galactomannan extracted from the seeds of Leucaena leucocephala was sulfated chemically, yielding a polymer (LLS-2) with 15.2% sulfate by weight (degree of sulfation 0.60), and its effect on the replication of Herpes simplex virus 1 (HSV-1) in Vero cells was investigated. When added during infection and early replication, LLS-2 showed 93.7% inhibition of HSV-1 replication at a concentration of 2.5 μg/mL, according to the reduction in the number of viral plaques, and a selectivity index higher than 1,000, suggesting that it inhibits HSV-1 binding to the host cell. | ||
| 546 | |a EN | ||
| 690 | |a leucaena leucocephala. galactomannan. sulfation. hsv-1; antiviral activity | ||
| 690 | |a Pharmaceutical industry | ||
| 690 | |a HD9665-9675 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Revista de Ciências Farmacêuticas Básica e Aplicada, Vol 31, Iss 2 (2010) | |
| 787 | 0 | |n http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/397 | |
| 787 | 0 | |n https://doaj.org/toc/1808-4532 | |
| 787 | 0 | |n https://doaj.org/toc/2179-443X | |
| 856 | 4 | 1 | |u https://doaj.org/article/be9b1ea6a5e9481f95e2cce7ad3b7536 |z Connect to this object online. |