Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate
Methylphenidate (MPH) and methamphetamine (METH) are the current treatments of choice for attention deficit/hyperactivity disorder. We previously reported that METH induces the release of dopamine (DA) and of the neurotransmitter candidate L-3,4-dihydroxyphenylalanine (L-DOPA). In contrast, we here...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2023-07-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_bf13d8cb1e454bee9ed6ece9b6aa3f36 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hiraku Uchimura |e author |
| 700 | 1 | 0 | |a Kaori Kanai |e author |
| 700 | 1 | 0 | |a Masami Arai |e author |
| 700 | 1 | 0 | |a Miyu Inoue |e author |
| 700 | 1 | 0 | |a Akitoyo Hishimoto |e author |
| 700 | 1 | 0 | |a Daiki Masukawa |e author |
| 700 | 1 | 0 | |a Yoshio Goshima |e author |
| 245 | 0 | 0 | |a Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate |
| 260 | |b Elsevier, |c 2023-07-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2023.04.006 | ||
| 520 | |a Methylphenidate (MPH) and methamphetamine (METH) are the current treatments of choice for attention deficit/hyperactivity disorder. We previously reported that METH induces the release of dopamine (DA) and of the neurotransmitter candidate L-3,4-dihydroxyphenylalanine (L-DOPA). In contrast, we here found that MPH increased the DA release while it did not affect the L-DOPA release from the dorsolateral striatum. Nevertheless, MPH-induced hyperlocomotion was reduced in Gpr143 (L-DOPA receptor) gene-deficient (Gpr143−/y) mice. The rewarding effect and increased c-fos expression induced by MPH were also attenuated in Gpr143−/y mice. Together, these findings suggest that GPR143 is involved in the acute and chronic actions of MPH. | ||
| 546 | |a EN | ||
| 690 | |a L-DOPA | ||
| 690 | |a GPR143 | ||
| 690 | |a Methylphenidate | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 152, Iss 3, Pp 178-181 (2023) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861323000282 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/bf13d8cb1e454bee9ed6ece9b6aa3f36 |z Connect to this object online. |