Transmembrane Phosphatase with TEnsin Homologue (TPTE) Expression in Epithelial Ovarian Cancer
Background: TPTE is a 'Cancer Testis' antigen that could be a candidate for targeted immunotherapy of epithelial ovarian cancer. Objective: To determine the prevalence of expression and the impact of TPTE on clinical and survival outcomes in epithelial ovarian cancer. Methods: Relevant med...
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Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu,
2022-06-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_bf29e3745e6d4f2b98f5f3b9c2c17ba8 | ||
042 | |a dc | ||
100 | 1 | 0 | |a CA Adepiti |e author |
700 | 1 | 0 | |a K Odunsi |e author |
245 | 0 | 0 | |a Transmembrane Phosphatase with TEnsin Homologue (TPTE) Expression in Epithelial Ovarian Cancer |
260 | |b Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu, |c 2022-06-01T00:00:00Z. | ||
500 | |a 10.30442/ahr.0802-04-163 | ||
500 | |a 2476-8642 | ||
500 | |a 2536-6149 | ||
520 | |a Background: TPTE is a 'Cancer Testis' antigen that could be a candidate for targeted immunotherapy of epithelial ovarian cancer. Objective: To determine the prevalence of expression and the impact of TPTE on clinical and survival outcomes in epithelial ovarian cancer. Methods: Relevant medical information of 173 ovarian cancer patients (including Fallopian and primary peritoneal) managed at a Cancer Centre were retrieved. Reverse-transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of TPTE in the tumours. TPTE expression was correlated with the clinicopathologic and survival outcomes of the patients. Results: TPTE was expressed by 45.1% (78/173) of the tested tumours. There was no significant difference in age between TPTE-positive and negative women (p = 0.93). TPTE expression was not significantly associated with the stage of the disease (p = 1.00), grade of disease (p = 0.71) and histology of the tumour (p = 0.17). There was no significant association between TPTE expression and the ease of optimum debulking (44.5% vs 44.3%, p = 0.54). TPTE expression was also not associated with a better response to therapy (p = 0.05). However, it was associated with slightly longer but not statistically significant progression-free survival (27.5 vs 20.6-months, p = 0.14) and overall survival (49.2 vs 28.0 months, p = 0.11). Conclusion: This study shows that TPTE is expressed at a moderate frequency in epithelial ovarian cancers, and its expression is associated with marginally better survival outcomes. | ||
546 | |a EN | ||
690 | |a antigen-specific immunotherapy | ||
690 | |a 'cancer testis' antigen | ||
690 | |a epithelial ovarian cancer | ||
690 | |a etpte | ||
690 | |a ny-eso-1 | ||
690 | |a Medicine (General) | ||
690 | |a R5-920 | ||
690 | |a Public aspects of medicine | ||
690 | |a RA1-1270 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Annals of Health Research, Vol 8, Iss 2, Pp 121-130 (2022) | |
787 | 0 | |n https://www.annalsofhealthresearch.com/index.php/ahr/article/view/414 | |
787 | 0 | |n https://doaj.org/toc/2476-8642 | |
787 | 0 | |n https://doaj.org/toc/2536-6149 | |
856 | 4 | 1 | |u https://doaj.org/article/bf29e3745e6d4f2b98f5f3b9c2c17ba8 |z Connect to this object online. |