Transmembrane Phosphatase with TEnsin Homologue (TPTE) Expression in Epithelial Ovarian Cancer

Background: TPTE is a 'Cancer Testis' antigen that could be a candidate for targeted immunotherapy of epithelial ovarian cancer. Objective: To determine the prevalence of expression and the impact of TPTE on clinical and survival outcomes in epithelial ovarian cancer. Methods: Relevant med...

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Main Authors: CA Adepiti (Author), K Odunsi (Author)
Format: Book
Published: Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu, 2022-06-01T00:00:00Z.
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001 doaj_bf29e3745e6d4f2b98f5f3b9c2c17ba8
042 |a dc 
100 1 0 |a CA Adepiti  |e author 
700 1 0 |a K Odunsi  |e author 
245 0 0 |a Transmembrane Phosphatase with TEnsin Homologue (TPTE) Expression in Epithelial Ovarian Cancer 
260 |b Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu,   |c 2022-06-01T00:00:00Z. 
500 |a 10.30442/ahr.0802-04-163 
500 |a 2476-8642 
500 |a 2536-6149 
520 |a Background: TPTE is a 'Cancer Testis' antigen that could be a candidate for targeted immunotherapy of epithelial ovarian cancer. Objective: To determine the prevalence of expression and the impact of TPTE on clinical and survival outcomes in epithelial ovarian cancer. Methods: Relevant medical information of 173 ovarian cancer patients (including Fallopian and primary peritoneal) managed at a Cancer Centre were retrieved. Reverse-transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of TPTE in the tumours. TPTE expression was correlated with the clinicopathologic and survival outcomes of the patients. Results: TPTE was expressed by 45.1% (78/173) of the tested tumours. There was no significant difference in age between TPTE-positive and negative women (p = 0.93). TPTE expression was not significantly associated with the stage of the disease (p = 1.00), grade of disease (p = 0.71) and histology of the tumour (p = 0.17). There was no significant association between TPTE expression and the ease of optimum debulking (44.5% vs 44.3%, p = 0.54). TPTE expression was also not associated with a better response to therapy (p = 0.05). However, it was associated with slightly longer but not statistically significant progression-free survival (27.5 vs 20.6-months, p = 0.14) and overall survival (49.2 vs 28.0 months, p = 0.11). Conclusion: This study shows that TPTE is expressed at a moderate frequency in epithelial ovarian cancers, and its expression is associated with marginally better survival outcomes. 
546 |a EN 
690 |a antigen-specific immunotherapy 
690 |a 'cancer testis' antigen 
690 |a epithelial ovarian cancer 
690 |a etpte 
690 |a ny-eso-1 
690 |a Medicine (General) 
690 |a R5-920 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Annals of Health Research, Vol 8, Iss 2, Pp 121-130 (2022) 
787 0 |n https://www.annalsofhealthresearch.com/index.php/ahr/article/view/414 
787 0 |n https://doaj.org/toc/2476-8642 
787 0 |n https://doaj.org/toc/2536-6149 
856 4 1 |u https://doaj.org/article/bf29e3745e6d4f2b98f5f3b9c2c17ba8  |z Connect to this object online.