Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress

• Main Authors: Francisco V. Souza-Neto (Author), Fabian Islas (Author), Sara Jiménez-González (Author), María Luaces (Author), Bunty Ramchandani (Author), Ana Romero-Miranda (Author), Beatriz Delgado-Valero (Author), Elena Roldan-Molina (Author), Melchor Saiz-Pardo (Author), Mª Ángeles Cerón-Nieto (Author), Luis Ortega-Medina (Author), Ernesto Martínez-Martínez (Author), Victoria Cachofeiro (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have evaluated cardiac function and fibrosis in infarcted male Wistar rats treated with MitoQ (50 mg/kg/day) or vehicle for 4 weeks. A cohort of patients admitted with a first episode of acute MI were also analyzed with cardiac magnetic resonance and T1 mapping during admission and at a 12-month...