Effects of aqueous extract from Stephanolepis hispidus on blood pressure in the normal and in L-NAME-induced hypertensive rats

The present study was aimed to investigating the antihypertensive effect of the aqueous extract from skin fish Stephanolepis hispidus in normotensive and NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. The treatment of rats with L-NAME (60 mg/L, drinking water) caused a sustained inc...

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Main Authors: Ana Luiza Muccillo-Baisch (Author), Daniela Brum da Silva (Author), Andressa de Andrade (Author), Daniela Carrazzoni (Author), Marta Regina Cezar-Vaz (Author), Gianni Goulart Peraza (Author), Eliana Badiale Furlong (Author), Maria Cristina Flores Soares (Author)
Format: Book
Published: Universidade Federal Fluminense, Escola de Enfermagem Aurora de Afonso Costa, 2007-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Ana Luiza Muccillo-Baisch  |e author 
700 1 0 |a Daniela Brum da Silva  |e author 
700 1 0 |a Andressa de Andrade  |e author 
700 1 0 |a Daniela Carrazzoni  |e author 
700 1 0 |a Marta Regina Cezar-Vaz  |e author 
700 1 0 |a Gianni Goulart Peraza  |e author 
700 1 0 |a Eliana Badiale Furlong  |e author 
700 1 0 |a Maria Cristina Flores Soares  |e author 
245 0 0 |a Effects of aqueous extract from Stephanolepis hispidus on blood pressure in the normal and in L-NAME-induced hypertensive rats 
260 |b Universidade Federal Fluminense, Escola de Enfermagem Aurora de Afonso Costa,   |c 2007-08-01T00:00:00Z. 
500 |a 1676-4285 
520 |a The present study was aimed to investigating the antihypertensive effect of the aqueous extract from skin fish Stephanolepis hispidus in normotensive and NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. The treatment of rats with L-NAME (60 mg/L, drinking water) caused a sustained increased in rat blood pressure (BP). Aqueous extract of Stephanolepis hispidus (AqeSh) restored rat BP to normal levels in the L-NAME-treated hypertensive rats. Moreover, AqeSh was able to prevent the increase of BP induced by L-NAME. At the end of the treatment no difference in body weight and vital organs were noted between the control and treated groups. Hematological and biochemical studies revealed no differences in treated animal except AST and ALT profile, may due to the presence of L-NAME. These results suggest that oral administration of AqeSh prevent the increase of BP in L-NAME-induced hypertension that may be mediated partially by nitrite and nitrate present in the skin. 
546 |a EN 
546 |a ES 
546 |a PT 
690 |a Stephanolepis hispidus water extract 
690 |a LG-nitro-L-arginine methylester (L-NAME) 
690 |a hypertension 
690 |a Nitric oxide (NO) 
690 |a Nursing 
690 |a RT1-120 
655 7 |a article  |2 local 
786 0 |n Online Brazilian Journal of Nursing, Vol 6, Iss 2 (2007) 
787 0 |n http://www.objnursing.uff.br/index.php/nursing/article/view/836 
787 0 |n https://doaj.org/toc/1676-4285 
856 4 1 |u https://doaj.org/article/bf5bb746c2b14d0e9075ac8f697e04a2  |z Connect to this object online.