CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses

• Main Authors: Yang Xie (Author), Yuan Zhang (Author), Tianxiao Zhu (Author), Jingchang Ma (Author), Chujun Duan (Author), Lu Yang (Author), Tingting Wang (Author), Ran Zhuang (Author), Ka Bian (Author), Lianjun Lu (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Allergic rhinitis (AR) is an immunoglobulin E-mediated type 2 inflammation of the nasal mucosa that is mainly driven by type 2 helper T cells (Th2) and type 2 innate lymphoid cells (ILC2s). CD226 is a costimulatory molecule associated with inflammatory response and is mainly expressed on T cells, na...