On the criteria for the severity of Infectious mononucleosis in hospitalized children

• Main Authors: N. S. Pospelova (Author), N. O. Postanogova (Author), M. O. Satyukova (Author), A. Yu. Deryusheva (Author), A. V. Permyakova (Author)
• Format: Bog
• Udgivet: LLC "Diagnostics and Vaccines", 2020-03-01T00:00:00Z.
• Fag: article
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• Notes: 2072-8107; 10.22627/2072-8107-2020-19-1-26-28
• Keywords: infectious mononucleosis; epstein-barr virus; cytomegalovirus; children; bilirubin; Pediatrics; RJ1-570
• Source: Детские инфекции (Москва), Vol 19, Iss 1, Pp 26-28 (2020)

Purpose of the study. Justification of the practical application of laboratory criteria marking the severity of infectious mononucleosis in hospitalized children.Materials and methods. A comparative prospective clinical study involved 54 children, aged 2 to 13 years, median age 5 years [3.0; 8.7]. The main study group consisted of 27 children with a severity of the disease, the comparison group - 27 patients of moderate. We used the Mann-Whitney test, Spearman's correlation coefficient and mathematical modeling.Results. The study found a direct correlative relationship between the severity of infectious mononucleosis and indicators of total and direct bilirubin, r = 0.39. «Cut of» values were determined: for total bilirubin ≥ 15 µmol / L, for direct bilirubin ≥ 5.5 µmol / L, sensitivity 96%, specificity 52%.Conclusions. «Cut of» bilirubin fractions can be used to predict the severity of infectious mononucleosis in hospitalized children on the first day of the disease.