Combination therapy based on nano codelivery for overcoming cancer drug resistance
Multidrug resistance (MDR) has long been a major obstacle in the treatment of malignant tumors. Combination therapy provides a viable and promising strategy to overcome MDR. This article discusses the advantages of nano-based combination therapy and proposes a 3R delivery principle (right place, rig...
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| Main Authors: | , |
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| Format: | Book |
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Elsevier,
2020-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Multidrug resistance (MDR) has long been a major obstacle in the treatment of malignant tumors. Combination therapy provides a viable and promising strategy to overcome MDR. This article discusses the advantages of nano-based combination therapy and proposes a 3R delivery principle (right place, right time, and right dose) as a reference for development of cancer nanomedicine containing drug combinations. The article also reviews the strategies of nano-based codelivery, with emphasis on the techniques designed to overcome chemoresistance, enhance drug targeting delivery, and reduce immunosuppression. |
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| Item Description: | 2590-0986 10.1016/j.medidd.2020.100024 |