A System for Discovering Novel Uricosurics Targeting Urate Transporter 1 Based on In Vitro and In Vivo Modeling

• Những tác giả chính: Xuechen Li (Tác giả), Chufan Qi (Tác giả), Mengjie Shao (Tác giả), Yajun Yang (Tác giả), Yuying Wang (Tác giả), Jiang Li (Tác giả), Zhiyan Xiao (Tác giả), Fei Ye (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2024-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Hyperuricemia has become a global burden with the increasing prevalence and risk of associated metabolic disorders and cardiovascular diseases. Uricosurics act as a vital urate-lowering therapy by promoting uric acid excretion via the kidneys. However, potent and safe uricosurics are still in urgent...