The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells

• Main Authors: Dan-dan Xu (Author), Ying Wang (Author), Peng-jun Zhou (Author), Shu-rong Qin (Author), Rong Zhang (Author), Yi Zhang (Author), Xue Xue (Author), Jianping Wang (Author), Xia Wang (Author), Hong-ce Chen (Author), Xiao Wang (Author), Yu-wei Pan (Author), Li Zhang (Author), Hai-zhao Yan (Author), Qiu-ying Liu (Author), Zhong Liu (Author), Su-hong Chen (Author), Hong-yuan Chen (Author), Yi-fei Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute myeloid leukemia is an aggressive disease characterized by clonal proliferation and differentiation into immature hematopoietic cells of dysfunctional myeloid precursors. Accumulating evidence shows that CD34+CD38- leukemia stem cells (LSCs) are responsible for drug resistance, metastasis, and...