Optimization of Ultrasound-assisted Acidic-solvent Extraction of Colchicine from Colchicum kurdicum (Bornm.) Stef. Using Response Surface Methodology
<strong>Background and objectives: </strong><em>Colchicum kurdicum</em> (Bornm.) Stef. is a flowering perennial monocotyledon plant that has many important bioactive compounds especially colchicine and colchicine derivatives. In this study, the ultrasound-assisted acidic-solv...
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Iranian Society of Pharmacognosy,
2020-07-01T00:00:00Z.
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| 001 | doaj_c0164c6fe93f45b38bc9dbd06de890f5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mohammad Azadbakht |e author |
| 700 | 1 | 0 | |a Elnaz Khoshvishkaie |e author |
| 700 | 1 | 0 | |a Ali Davoodi* |e author |
| 700 | 1 | 0 | |a Seyed Jalal Hosseinimehr |e author |
| 700 | 1 | 0 | |a Masoud Azadbakht |e author |
| 700 | 1 | 0 | |a Saeed Emami |e author |
| 700 | 1 | 0 | |a Hossein Bakhshi Jouybari |e author |
| 700 | 1 | 0 | |a Fatemeh Mirzaee |e author |
| 700 | 1 | 0 | |a Kiana Ghadiri |e author |
| 245 | 0 | 0 | |a Optimization of Ultrasound-assisted Acidic-solvent Extraction of Colchicine from Colchicum kurdicum (Bornm.) Stef. Using Response Surface Methodology |
| 260 | |b Iranian Society of Pharmacognosy, |c 2020-07-01T00:00:00Z. | ||
| 500 | |a 2345-4458 | ||
| 500 | |a 2345-5977 | ||
| 500 | |a 10.22127/rjp.2020.219998.1558 | ||
| 520 | |a <strong>Background and objectives: </strong><em>Colchicum kurdicum</em> (Bornm.) Stef. is a flowering perennial monocotyledon plant that has many important bioactive compounds especially colchicine and colchicine derivatives. In this study, the ultrasound-assisted acidic-solvent extraction method coupled with response-surface method was presented as the successful method for large scale extraction of colchicine as an alkaloid compound from <em>Colchicum kurdicum</em>. <strong>Methods: </strong>According to the literatures, methanol/deionized water (70:30) solvent system was selected for the extraction. In addition, the response-surface method was used for analysis and optimization of colchicine extraction by ultrasonic-assisted acidic-solvent extraction method. Subsequently, colchicine was extracted using this method and the effects of solvent pH, extraction time, solvent/plant ratio, power, and temperature were evaluated. <strong>Results: </strong>After all analysis procedures, 0.99 mg colchicine/g dried corms was achieved with the following conditions: solvent pH 4, Extraction time 120 minutes, solvent/plant ratio 20 mL/g, power 100 W, and temperature 60 ºC. <strong>Conclusion: </strong>According to this study, ultrasonic-assisted acidic-solvent extraction was found an effective method for extraction of colchicine from <em>Colchicum kurdicum </em>(Bornm.) Stef. compared to other extraction methods. | ||
| 546 | |a EN | ||
| 690 | |a colchicine | ||
| 690 | |a colchicum kurdicum | ||
| 690 | |a extraction | ||
| 690 | |a hplc | ||
| 690 | |a ultrasound | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Research Journal of Pharmacognosy, Vol 7, Iss 3, Pp 5-13 (2020) | |
| 787 | 0 | |n http://www.rjpharmacognosy.ir/article_106223_474d4bcd067bd3a52186d0e30604f630.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2345-4458 | |
| 787 | 0 | |n https://doaj.org/toc/2345-5977 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c0164c6fe93f45b38bc9dbd06de890f5 |z Connect to this object online. |