External Evaluation of Population Pharmacokinetic Models of Methotrexate for Model-Informed Precision Dosing in Pediatric Patients with Acute Lymphoid Leukemia

• Главные авторы: Shengfeng Wang (Автор), Qiufen Yin (Автор), Minghua Yang (Автор), Zeneng Cheng (Автор), Feifan Xie (Автор)
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• Опубликовано: MDPI AG, 2023-02-01T00:00:00Z.
• Предметы: article
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Background: Methotrexate (MTX) is a key immunosuppressant for children with acute lymphoid leukemia (ALL), and it has a narrow therapeutic window and relatively high pharmacokinetic variability. Several population pharmacokinetic (PopPK) models of MTX in ALL children have been reported, but the vali...