Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer

• Main Authors: Li-qian Ci (Author), Zhi-gang Huang (Author), Feng-mei Lv (Author), Jun Wang (Author), Ling-lin Feng (Author), Feng Sun (Author), Shui-juan Cao (Author), Zhe-peng Liu (Author), Yu Liu (Author), Gang Wei (Author), Wei-yue Lu (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was carried out to investigate the potential of cationic functionalization on imatinib nanocrystals to improve the mucoadhesiveness and, thus, delivery to the lesion of cervicovaginal tumors. Amino-group-functionalized imatinib nanocrystals (NC@PDA-NH2) were prepared with near-sphe...