N-linked glycosylation of the West Nile virus envelope protein is not a requisite for avian virulence or vector competence.

• Main Authors: Payal D Maharaj (Author), Stanley A Langevin (Author), Bethany G Bolling (Author), Christy C Andrade (Author), Xavier A Engle (Author), Wanichaya N Ramey (Author), Angela Bosco-Lauth (Author), Richard A Bowen (Author), Todd A Sanders (Author), Claire Y-H Huang (Author), William K Reisen (Author), Aaron C Brault (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence. Naturally occurring isolates with altered E protein glycosylation patterns have been observe...