Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy
Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis and inflammation. Our group previously identified TAK-632 (5) as an effective necroptosis inhibitor by dual-targeting RIP1 and RIP3. In this st...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2021-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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