Effect of Gut Microbiota on the Pharmacokinetics of Nifedipine in Spontaneously Hypertensive Rats

• Main Authors: Rong Zhou (Author), Haijun Yang (Author), Peng Zhu (Author), Yujie Liu (Author), Yanjuan Zhang (Author), Wei Zhang (Author), Honghao Zhou (Author), Xiong Li (Author), Qing Li (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetic variability of nifedipine widely observed in the clinic cannot be fully explained by pharmacogenomics. As a new factor affecting drug metabolism, how the gut microbiota affects the pharmacokinetics of nifedipine needs to be explored. Spontaneously hypertensive rats (SHRs) have be...