Relationship Between Cytokines in Ascites and the Severity of Ovarian Hyperstimulation Syndrome: A Case Report

• Main Authors: Ming-Tzeung Chung (Author), Shao-Pai Wu (Author)
• Format: Book
• Published: Elsevier, 2004-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1028-4559; 10.1016/S1028-4559(09)60065-6
• Keywords: ovarian hyperstimulation syndrome; interleukin-1; interleukin-6; interleukin-8; tumor necrosis factor; vascular endothelial growth factor; Gynecology and obstetrics; RG1-991
• Source: Taiwanese Journal of Obstetrics & Gynecology, Vol 43, Iss 2, Pp 107-109 (2004)

Objective: Determination of the correlation of interleukin-1 (IL-1), IL-6, IL-8, tumor necrosis factor (TNF), and vascular endothelial growth factor (VEGF) levels in serum and ascites with the severity of ovarian hyperstimulation syndrome (OHSS). Case Report: We present the case of a woman with primary infertility who was enrolled in an ovulation induction program. OHSS developed 6 days after artificial insemination with the husband's sperm. We performed continuous paracentesis and recorded daily concentrations of IL-1, IL-6, IL-8, TNF, and VEGF in serum and ascites in an attempt to determine their correlation with the severity of OHSS. Conclusion: Improvement in symptoms and a decreasing amount of ascites were correlated with a decreasing serum concentration of VEGF.