Determining Reference Ranges for Total T<sub>4</sub> in Dried Blood Samples for Newborn Screening
The purpose of this study was to define reference intervals for total thyroxine (tT<sub>4</sub>) in dried blood samples (DBSs) obtained for newborn screening. The aim of our study was to assess the possible benefit of measuring tT<sub>4</sub> concentrations directly in DBSs o...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Published: |
MDPI AG,
2020-03-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The purpose of this study was to define reference intervals for total thyroxine (tT<sub>4</sub>) in dried blood samples (DBSs) obtained for newborn screening. The aim of our study was to assess the possible benefit of measuring tT<sub>4</sub> concentrations directly in DBSs obtained for newborn screening in premature and term-born infants. In order to have a sufficient number of samples for the extremely premature infants (<30 weeks), we set up a retrospective study, measuring the concentrations in DBSs collected over the previous 21 weeks. This time frame was a result of the included miniature study of tT<sub>4</sub> stability in DBSs. We found that tT<sub>4</sub> strongly correlated with gestational age (GA) in premature infants, highlighting the need for age-specific reference ranges. For term-born infants, the tT<sub>4</sub> ranges did not vary significantly among different gestational ages, allowing for the use of one single reference range. |
|---|---|
| Item Description: | 2409-515X 10.3390/ijns6010017 |