Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4

P2X receptors are a family of ATP-gated cation channels comprising seven subtypes in mammals, which play key roles in nerve transmission, pain sensation and inflammation. The P2X4 receptor in particular has attracted significant interest from pharmaceutical companies due to its physiological roles i...

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Bibliographic Details
Main Authors: Gaia Pasqualetto (Author), Marika Zuanon (Author), Andrea Brancale (Author), Mark T. Young (Author)
Format: Book
Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
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