Optimization of Initial Dose Regimen for Sirolimus in Pediatric Patients With Lymphangioma

• Main Authors: Xiao Chen (Author), Dongdong Wang (Author), Guangfei Wang (Author), Yidie Huang (Author), Xin Yu (Author), Jinmiao Lu (Author), Xiaowen Zhai (Author), Hong Xu (Author), Zhiping Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirolimus is an effective oral treatment for pediatric patients with lymphangioma. The present clinical study in 15 children (0.12-16.39 years of age) examines the effects of underlying factors on sirolimus concentrations through application of a population pharmacokinetic model. Using Monte Carlo s...