Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia

Background. Persistent elevation in beta-human chorionic gonadotropin (β-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process. Case. A 34-year-old G3P3 presented with elevated β-h...

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Main Authors: Conner Blackwell (Author), Shian McLeish (Author), David Iglesias (Author), Shannon D. Armbruster (Author)
Format: Book
Published: Hindawi Limited, 2023-01-01T00:00:00Z.
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100 1 0 |a Conner Blackwell  |e author 
700 1 0 |a Shian McLeish  |e author 
700 1 0 |a David Iglesias  |e author 
700 1 0 |a Shannon D. Armbruster  |e author 
245 0 0 |a Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia 
260 |b Hindawi Limited,   |c 2023-01-01T00:00:00Z. 
500 |a 2090-6692 
500 |a 10.1155/2023/1901858 
520 |a Background. Persistent elevation in beta-human chorionic gonadotropin (β-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process. Case. A 34-year-old G3P3 presented with elevated β-hCG four months after cesarean delivery with bilateral tubal ligation. The patient was treated with methotrexate for a presumed new ectopic pregnancy. Due to persistent β-hCG elevation, she received actinomycin-D for GTN treatment. After completing chemotherapy, her β-hCG increased. The patient underwent a laparoscopic hysterectomy with unplanned left oophorectomy due to its nodular appearance at the time of surgery. Pathology confirmed a dysgerminoma of the ovary and benign uterus. Conclusion. Although dysgerminomas are uncommon, they should be considered when β-hCG levels remain elevated despite therapies for more common pathologies. 
546 |a EN 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
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786 0 |n Case Reports in Obstetrics and Gynecology, Vol 2023 (2023) 
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787 0 |n https://doaj.org/toc/2090-6692 
856 4 1 |u https://doaj.org/article/c154e5257f5d475599346607674fe19f  |z Connect to this object online.