Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China

In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptabilit...

Full description

Saved in:
Bibliographic Details
Main Authors: Hui Yao (Author), Ying Shen (Author), Zhichao Liang (Author), Xiaoyu Xue (Author), Chenxi Zhao (Author), Xiang Xu (Author), Yuxin Cai (Author), Yonghong Liu (Author), Wei Zhang (Author), Yang Pan (Author), Xiaoli Wang (Author)
Format: Book
Published: Elsevier, 2024-04-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_c179e7f68cd24ece9355eee2a1ef802c
042 |a dc 
100 1 0 |a Hui Yao  |e author 
700 1 0 |a Ying Shen  |e author 
700 1 0 |a Zhichao Liang  |e author 
700 1 0 |a Xiaoyu Xue  |e author 
700 1 0 |a Chenxi Zhao  |e author 
700 1 0 |a Xiang Xu  |e author 
700 1 0 |a Yuxin Cai  |e author 
700 1 0 |a Yonghong Liu  |e author 
700 1 0 |a Wei Zhang  |e author 
700 1 0 |a Yang Pan  |e author 
700 1 0 |a Xiaoli Wang  |e author 
245 0 0 |a Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China 
260 |b Elsevier,   |c 2024-04-01T00:00:00Z. 
500 |a 2590-0536 
500 |a 10.1016/j.bsheal.2024.03.002 
520 |a In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.0 %, the specificities were 92.6 % and 93.8 %, respectively. The results of an acceptability survey showed that the scores for saliva, OP, and NP samples were 9.46 ± 1.69, 8.11 ± 2.42, and 4.58 ± 3.82 out of 10, respectively, with significant differences among the three groups (P < 0.05). With higher sensitivity, comparable specificity, and strong public preference, saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics. 
546 |a EN 
690 |a SARS-CoV-2 
690 |a Saliva sample 
690 |a Sensitivity 
690 |a Acceptability 
690 |a Infectious and parasitic diseases 
690 |a RC109-216 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Biosafety and Health, Vol 6, Iss 2, Pp 88-91 (2024) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2590053624000296 
787 0 |n https://doaj.org/toc/2590-0536 
856 4 1 |u https://doaj.org/article/c179e7f68cd24ece9355eee2a1ef802c  |z Connect to this object online.