Genetics and genomics in IBS: A primer for the neurogastroenterologist
Irritable bowel syndrome (IBS) is a gut-brain interaction disorder characterized by recurrent or chronic abdominal pain associated with an alteration in the normal pattern of stool consistency. In more than 20% of patients with IBS, there is comorbidity with depression and anxiety impacting on quali...
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| Main Authors: | , |
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| Format: | Book |
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Permanyer,
2021-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Irritable bowel syndrome (IBS) is a gut-brain interaction disorder characterized by recurrent or chronic abdominal pain associated with an alteration in the normal pattern of stool consistency. In more than 20% of patients with IBS, there is comorbidity with depression and anxiety impacting on quality of life. The pathophysiology of IBS is not fully understood, but it involves the neural, endocrine, and immune systems as dysfunctional signaling processes of the gut-brain axis. The goal of this review is to prime neurogastroenterologist into genetic or genomic studies. We will describe the different strategies used to discover the genes involved in the development of IBS. We will briefly explain general considerations for genetic studies, the different cohorts used for genetic studies (familial, case-control, general population), and approaches used for these studies (candidate genes or genome wide- association studies [GWAS]). Moreover, we will describe some of the genes associated with IBS. Genetic and genomic studies have been crucial to identify several gene variants associated with IBS. |
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| Item Description: | 10.24875/NGL.21000012 2462-7011 |