Tocilizumab for the Treatment of Mevalonate Kinase Deficiency

• Main Authors: Nadia K. Rafiq (Author), Helen Lachmann (Author), Frodi Joensen (Author), Troels Herlin (Author), Paul A. Brogan (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mevalonate kinase deficiency (MKD) is a severe autoinflammatory disease caused by recessive mutations in MVK resulting in reduced function of the enzyme mevalonate kinase, involved in the cholesterol/isoprenoid pathway. MKD presents with periodic episodes of severe systemic inflammation, poor qualit...