Alveolar Proteinosis Secondary to <i>M. tuberculosis</i>, in a Patient with Transient CD4 Lymphocytopenia Due to <i>Cryptococcus neoformans</i> Infection: First Case in the Literature

Transient CD4 lymphocytopenia is defined as the transitory presence of CD4+ T lymphocyte fewer than 300 cells/mm<sup>3</sup> or less than 20% of T cells without HIV infection. It can occur due to multiple causes; however, it is rare for it to occur due to opportunistic infections. Few ca...

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Main Authors: Daniel Augusto Martin Arsanios (Author), Diego Alejandro Cubides-Díaz (Author), Natalia Muñoz-Angulo (Author), Maria Alejandra Perez-Hernandez (Author), Marlyn Zamora Posada (Author), Mónica Briceño Torres (Author), Carlos Mauricio Calderón Vargas (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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Summary:Transient CD4 lymphocytopenia is defined as the transitory presence of CD4+ T lymphocyte fewer than 300 cells/mm<sup>3</sup> or less than 20% of T cells without HIV infection. It can occur due to multiple causes; however, it is rare for it to occur due to opportunistic infections. Few cases have been described in the literature where antimicrobial treatment normalizes the CD4 count, being more frequent in <i>Mycobacterium tuberculosis</i> infections. To date, this phenomenon has not been described in <i>Cryptococcus neoformans</i> infections. This would be the first reported case according to our knowledge, of a patient who normalizes CD4 count after antifungal treatment, later developing alveolar proteinosis due to <i>M. Tuberculosis.</i>
Item Description:10.3390/idr14020021
2036-7449