SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS

• Main Authors: Federica Barreca (Author), Michele Aventaggiato (Author), Laura Vitiello (Author), Luigi Sansone (Author), Matteo Antonio Russo (Author), Antonello Mai (Author), Sergio Valente (Author), Marco Tafani (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative subtype, have a high expression of GLS. Our recent study demonstrated that GLS activity and ammonia production are inhibited...