Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide

We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Koji Dogishi (Awdur), Mizuki Kodera (Awdur), Shohei Oyama (Awdur), Hisashi Shirakawa (Awdur), Takayuki Nakagawa (Awdur), Shuji Kaneko (Awdur)
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Cyhoeddwyd: Elsevier, 2015-12-01T00:00:00Z.
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Crynodeb:We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition.
Disgrifiad o'r Eitem:1347-8613
10.1016/j.jphs.2015.11.003