Trends in H<sub>2</sub>S-Donors Chemistry and Their Effects in Cardiovascular Diseases
Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a significant role in many physio-pathologic...
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MDPI AG,
2021-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_c1dc4306891e4acf9cfcd427e6e8c3a8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Angela Corvino |e author |
| 700 | 1 | 0 | |a Francesco Frecentese |e author |
| 700 | 1 | 0 | |a Elisa Magli |e author |
| 700 | 1 | 0 | |a Elisa Perissutti |e author |
| 700 | 1 | 0 | |a Vincenzo Santagada |e author |
| 700 | 1 | 0 | |a Antonia Scognamiglio |e author |
| 700 | 1 | 0 | |a Giuseppe Caliendo |e author |
| 700 | 1 | 0 | |a Ferdinando Fiorino |e author |
| 700 | 1 | 0 | |a Beatrice Severino |e author |
| 245 | 0 | 0 | |a Trends in H<sub>2</sub>S-Donors Chemistry and Their Effects in Cardiovascular Diseases |
| 260 | |b MDPI AG, |c 2021-03-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox10030429 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a significant role in many physio-pathological processes, such as inflammation, oxidation, neurophysiology, ion channels regulation, cardiovascular protection, endocrine regulation, and tumor progression. Considering the plethora of physiological effects of this gasotransmitter, the protective role of H<sub>2</sub>S donors in different disease models has been extensively studied. Based on the growing interest in H<sub>2</sub>S-releasing compounds and their importance as tools for biological and pharmacological studies, this review is an exploration of currently available H<sub>2</sub>S donors, classifying them by the H<sub>2</sub>S-releasing-triggered mechanism and highlighting those potentially useful as promising drugs in the treatment of cardiovascular diseases. | ||
| 546 | |a EN | ||
| 690 | |a hydrogen sulfide | ||
| 690 | |a natural H<sub>2</sub>S donors | ||
| 690 | |a synthetic H<sub>2</sub>S donors | ||
| 690 | |a triggered mechanism | ||
| 690 | |a H<sub>2</sub>S release | ||
| 690 | |a cardiovascular diseases | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 10, Iss 3, p 429 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/10/3/429 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c1dc4306891e4acf9cfcd427e6e8c3a8 |z Connect to this object online. |