Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation

• Päätekijät: Dimitrios T. Trafalis (Tekijä), Sofia Sagredou (Tekijä), Panayiotis Dalezis (Tekijä), Maria Voura (Tekijä), Stella Fountoulaki (Tekijä), Nikolaos Nikoleousakos (Tekijä), Konstantinos Almpanakis (Tekijä), Maria V. Deligiorgi (Tekijä), Vasiliki Sarli (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2021-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties. A series of 1,2,4-triazolo[3,4-<i>b</i>]-1,2,4-thiadiazoles was synthesized and tested for its enzyme inhibition potential and anti...