Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation

• Main Authors: Dimitrios T. Trafalis (Author), Sofia Sagredou (Author), Panayiotis Dalezis (Author), Maria Voura (Author), Stella Fountoulaki (Author), Nikolaos Nikoleousakos (Author), Konstantinos Almpanakis (Author), Maria V. Deligiorgi (Author), Vasiliki Sarli (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties. A series of 1,2,4-triazolo[3,4-<i>b</i>]-1,2,4-thiadiazoles was synthesized and tested for its enzyme inhibition potential and anti...