FRET Assays for the Identification of <i>C. albicans</i> HSP90-Sba1 and <i>Human</i> HSP90α-p23 Binding Inhibitors

• Autori principali: Philip Kohlmann (Autore), Sergey N. Krylov (Autore), Pascal Marchand (Autore), Joachim Jose (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2024-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Heat shock protein 90 (HSP90) is a critical target for anticancer and anti-fungal-infection therapies due to its central role as a molecular chaperone involved in protein folding and activation. In this study, we developed <i>in vitro</i> Förster Resonance Energy Transfer (FRET) assays t...