Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice

• Main Authors: Satoshi Mizutani (Author), Junko Nishio (Author), Kanoh Kondo (Author), Kaori Motomura (Author), Zento Yamada (Author), Shotaro Masuoka (Author), Soichi Yamada (Author), Sei Muraoka (Author), Naoto Ishii (Author), Yoshikazu Kuboi (Author), Sho Sendo (Author), Tetuo Mikami (Author), Toshio Imai (Author), Toshihiro Nanki (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CX3C Motif Chemokine Ligand 1 (CX3CL1; fractalkine) has been implicated in the pathogenesis of rheumatoid arthritis (RA) and its inhibition was found to attenuate arthritis in mice as well as in a clinical trial. Therefore, we investigated the effects of an anti-CX3CL1 monoclonal antibody (mAb) on i...