Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• المؤلفون الرئيسيون: Jian Xin (مؤلف), Min Hu (مؤلف), Qian Liu (مؤلف), Tian Tai Zhang (مؤلف), Dong Mei Wang (مؤلف), Song Wu (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...