Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Prif Awduron: Jian Xin (Awdur), Min Hu (Awdur), Qian Liu (Awdur), Tian Tai Zhang (Awdur), Dong Mei Wang (Awdur), Song Wu (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...