Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Hauptverfasser: Jian Xin (Verfasst von), Min Hu (Verfasst von), Qian Liu (Verfasst von), Tian Tai Zhang (Verfasst von), Dong Mei Wang (Verfasst von), Song Wu (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...