Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Κύριοι συγγραφείς: Jian Xin (Συγγραφέας), Min Hu (Συγγραφέας), Qian Liu (Συγγραφέας), Tian Tai Zhang (Συγγραφέας), Dong Mei Wang (Συγγραφέας), Song Wu (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...